I strongly doubt it. Statscan methodologies define a downtown as the densest area of employment, plus a 1 km buffer, so the thing that would make our downtown area spatially larger would not be population growth, but more employment near the core (but at densities similar to the very high ones there).
Further, under the Statscan methodology, our downtown would include Lower Mount Royal (at least as far west as 11 St), the north end of Mission/Cliff Bungalow (probably to 21st Ave), the south part of Crescent Heights (probably south of 7th Ave), most if not all of Sunnyside and Hillhurst south of Gladstone Rd and east of 14th St. Roughly 12-15K people.
But the final step in their methodology after producing the downtown area is "check with the municipality and follow their suggestions", and our Statscan downtown matches with the City's definition of the Centre City, so my strong assumption is that Statscan received the feedback that the City would prefer the areas to align. Since we're not changing that policy definition any time soon, the downtown won't change any time soon either.